Stephen Adele

Keepin' Estrogen in Check—P-450™

The Science of Isa-Test, Part III

By Stephen Adele

More Muscle Mass. More Strength. More Sexual Drive. These are all reasons men around the world are interested in testosterone and how to raise it.

There are numerous products, however, that provide more side effects than results (e.g., prohormones). Others that have dubious histories when it comes to safety (e.g., pro-steroids). And many, many more that just flat out don't work.

Yet nature has provided some very interesting, safe solutions. And science has recently shown that while testosterone is important, it's just as important to keep your estrogen in check. That's where P-450™ Hesperetin ([(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-H-1-benzopy-ran-4-one]) comes into play.

As an anti-aromatase, P-450™ hesperetin, found in the new, advanced Isa-Test, reduces the formation of estrogen in the body.

Hesperetin is an interesting citrus bioflavonoid found primarily in oranges and lemons. The antioxidant properties of hesperetin are fairly well established, and more recent studies have indicated hesperetin may also have anti-inflammatory, anti-allergic, hypolipidemic (reduces total cholesterol, including LDL), vasoprotective, and anti-carcinogenic actions. But a newly discovered, added benefit of this substance may be even more profound for weight trainers since hesperetin appears to be a potent anti-aromatase.

See, aromatase is the enzyme that is involved in the process through which hormones in the body are converted to estrogen. As an anti-aromatase, hesperetin reduces the formation of estrogen in the body. This is important because the conversion of testosterone to estrogen is thought to increase as we age (at least in males), and because increases in estrogen are linked to a whole host of unwanted side effects, like increased bodyfat, testicular shutdown, water retention, and in extreme cases, even gynecomastia (a "female breast-like" appearance) or testicular cancer.

What's interesting is that no one has used this powerful anti-estrogen compound—until recently that is. Probably because hesperetin was virtually unknown until recent research indicated its potential positive effects for inhibiting estrogen and because it takes an immense amount of resources to learn how to extract such a compound from its natural source.

Recently, however, hesperetin has been trademarked under the name P-450 and is now being made available to consumers under that name. If you'd like to use P-450™ (hesperetin) as a potent estrogen inhibitor, I'd stick to the most recent research and consume 200 mg at least once daily. And since it's a natural compound and it doesn't "shutdown" your body's natural production of T, you can use it for as long as you'd like.

Summary of Novel T-Boosting Supplements

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