The Scientific Construction of MX-LS7™

By Stephen Adele, Editor-in-Chief of Real Solutions, and CEO, iSatori

MX-LS7 is not to be taken lightly. It was designed for men and brave women who desire serious fat reduction. Fast.

At iSatori, scientific integrity and constant innovation are top priorities. And just as you consistently strive to improve your physique, the researchers at iSatori consistently strive to engineer more effective supplements... all in an effort to help you reach your goal—of physical perfection—faster.

This quest has resulted in the development of the new MX-LS7™—Maximum Strength Lean System 7, the High-Performance Fat Burner for Men. And, there's strong reason to believe this is iSatori's best work yet. What many are already considering the best fat-loss supplement ever created.

But what makes MX-LS7 so unique and so effective?

Well, we went straight to the top of iSatori Technologies, Founder and CEO Stephen Adele, and asked him to break down MX-LS7 and tell us exactly what is in it and how it works. Here's what he had to say about the three key complexes in the formula and how they've been researched to help you lose fat faster than you've ever believed possible...

1) The LS7 CORE COMPLEX™—High-Performance Thermogenesis to "Cut" Razor Sharp Abs

*7-Keto, which holds 10 U.S patents for weight loss, cognition, and health, has been shown to help our bodies burn more fat, faster, without the central nervous stimulating effects most thermogenics impart. This can be a real benefit for those who are sensitive to stimulants and those who wish to supplement for longer periods.

As an added bonus, 7-Keto also supports the immune system and helps prevent age-related health complications. "How does 7-Keto accomplish this?" you ask. Well, research by Lardy, et al., has shown that 7-Keto enhances the activity of three thermogenic enzymes, namely: glycerol-3-phosphate dehydrogenase, malic enzyme, and fatty acyl CoA oxidase.

These three enzymes impart several different effects, including driving energy-producing substrates in a direction of less efficient ATP production, thus enhancing thermogenesis or calorie-burning through heat.

Additionally, they promote the utilization of fat stores for energy and heat production. Thus, by driving both heat production and the utilization of adipose tissue (fat) stores, all without a "stimulating" effect, true, non-stimulant thermogenesis is achieved!

Ok, so we know how it works, but what effects can you expect to see? And just what has the real-world research shown? First and foremost, I must tell you about some work coming out of Dr. John Zenk's lab at the Minnesota Applied Research Center. He has been looking into the effects of 7-Keto on diet-induced metabolic decline.

Interestingly, subjects taking 7-Keto experience less of a decline in their metabolic rate than those taking a placebo. To you and me, this means we can maintain a higher baseline metabolic rate while consuming less calories. A definite win-win for those looking to drop bodyfat.

*Green Tea has notably become the "supplement of choice" for many seeking greater health and control over their weight. For good reason: not only does it have an interesting, appealing flavor when prepared as tea, science defends some astounding benefits when it's used as a supplement for immune enhancement and fat mobilization.

A recent study in Geneva showed that green tea is naturally packed with caffeine and very special compounds called "catechin polyphenols." This is of significant interest to those of us trying to reduce our weight because both of these substances have been documented to speed up resting metabolic rate or, more simply stated, rev up our bodies' calorie-burning potential.

To further support this theory, a study just released in Physiological Behavior (Auvichayapat P, et al, 2007) assessed green tea's effects on obese subjects. After 12 weeks of use, subjects had lost significantly more weight than those taking a placebo. Additionally, changes were noted in resting energy expenditure, thus confirming green tea's metabolic-enhancing effects.

Another study released in Obesity (Nagao T, et al 2007) showed similar findings. Here subjects again ingested green tea over the course of 12 weeks. Not only were reductions in bodyfat seen but additional findings noted reductions in systolic blood pressure and LDL cholesterol, thus decreasing both obesity and lessening the risk of cardiovascular disease. Other studies as well conducted by Dulloo AG and others have also documented green tea's lipolytic (fat-burning) effects through enhanced energy expenditure.

One of these studies I simply have to note is a study conducted by Chantre P, et al, 2002, which noted a 4.48% reduction in waist circumference after three months of consuming a 25% containing EGCG green tea. Now I know 4.48% reduction in WAIST circumference is of great interest to anyone reading this article.

So how does green tea do all this? You see, the compounds found in green tea allow our bodies to use bodyfat for energy (that is, it's "lipolytic") and enhance baseline energy utilization.

When stored calories are used for short-term energy, our bodies burn more fat. There are several theories as to how green tea imparts these effects. Notably, though, is that the polyphenols found in green tea may inhibit an enzyme called catechol-O-methyltransferase (COMT). This enzyme in particular breaks down the fat-fighting norepinephrine in our bodies. Thus, by inhibiting COMT, thermogenesis can be enhanced (Shixian Q, et al, 2006).

*Yerba mate is a perennial (a plant that doesn't die at the end of the year) and member of the holly family, evident by its leathery leaves. It grows wild in the rainforests of Argentina, Chile, Peru, Brazil, and Paraguay (where it is cultivated).

Some time back, native people used to chew the leaves of yerba mate for a quick boost of energy and eat it in foods for a true "power lunch." Later, people ground up the leaves and added them to cold water, but now those seeking natural boosts of energy and fat-fighting properties can benefit from yerba mate in a powdered supplement form.

Mate contains both caffeine and theobromine, both of which agonize adenosine receptors and enhance the half life of ATP. Compared to straight up caffeine, mate users generally report no jitteriness or anxiety. Perhaps this is due to mate's ability to inhibit MOA activity.

*Natural and Anhydrous Caffeine, in its purest form, has been used for centuries because of its natural stimulating effects, for a jolt of energy, to fight fatigue, and to delay muscle exhaustion. Caffeine also mobilizes fat for energy, which is ideal for those exercising and seeking to reduce bodyfat. We could go on all day about caffeine's effects and talk about adenosine receptor blockade and phosphodiesterase inhibition, but I think we're all pretty confident in caffeine's ability to rev us up and enhance fat mobilization.

*Bioperine is a patented standardized extract from the fruits of Piper nigrum L. (black pepper, a common household spice) or Piper longum L. (long pepper). It contains a minimum piperine content of 95% compared to the three to nine percent and three to five percent found in raw forms of Piper nigrum and Piper longum, respectively. Bioperine may be co-administered with various nutrients to assist in the uptake and use of those nutrients. Based on clinical data, having Bioperine in the digestive system with supplemented nutrients results in enhanced absorption. Studies show that when Bioperine is taken with other nutrients, it significantly increases the absorption of those nutrients.

*ADVANTRA-Z® (Synephrine or Citrus aurantium), commonly referred to as bitter orange, has been used for thousands of years in Traditional Chinese Medicine for improving and maintaining overall health. That is until recently, when science discovered compounds from the little orange fruits of Citrus aurantium, the most well-known being synephrine, demonstrated powerful thermogenic ("fat-burning" through heat) activity. Now, this herb is acclaimed as the "calmer chemical cousin" to ephedra because it increases the body's fat-burning mechanism—the metabolic rate—without producing the negative central nervous system and cardiovascular side effects. Hence, you get all of the metabolic-enhancing effects, without the stimulation and receptor burnout!

MX-LS7 contains only p(para)-synephrine, a stable isomer of the synephrine alkaloid. It is devoid of the m(meta)-synephrine, which has the potential for raising blood pressure and which may be found in generic bitter orange or synthetic synephrine.

2) T3 /cAMP ACTIVATOR BLEND™—Continuous, Round-the-Clock Fat Burning and Muscle Preservation

*Gugglesterone appears to preserve or increase thyroid activity by converting T4 (low-activity thyroid hormone) to T3 (high-activity thyroid hormone). T3 is responsible for regulating your metabolic rate, which affects the rate calories are burned. Work by Tripathi's group suggests an increase in the amount of iodine update by the thyroid along with enhanced activities of thyroid peroxidase are responsible for the thyroid-enhancing properties of guggul.

*Clary Sage is a fermented sage compound shown in unpublished in-vitro research to increase levels of a cellular messenger called cAMP (cyclic adenosine monophosphate). This is significant because in some metabolic processes, cAMP is involved in activating cellular enzymes and other substances that help move fat out of the fat cells (liberating fatty acids) and promote the weight-loss process.

To elaborate a bit more on this topic and lead into the next compound, one of the first steps needed to initiate the fat-burning process involves the release of norepinephrine, a chemical messenger that signals the release of epinephrine.

Once this occurs, these latch on to certain receptors, namely beta and alpha, that trigger an enzyme adenylate cyclase (AC) to convert ATP into cAMP. Call this the initiation of the fat-burning process. Ultimately, though, three key terms here are norepinphrine (enhanced by the core above), cAMP, and adenylate cylase all contribute to the process and metabolic utilization of fatty acids for use in ATP/energy production.

*Coleus forskohlii (FORSLEAN®) is an ancient patented Ayurvedic plant and member of the mint and lavender family, which grows in the mountains of Asia. Recent research has shown that the active ingredient in coleus is forskolin, which plays a major role in a variety of important cellular functions, including inhibiting histamine release, relaxing muscles, increasing thyroid function, and increasing fat-burning activity. The active chemical forskolin initiates a cascade of chemical reactions that cause fat cells to basically release their energy and shrink.

In more technical terms, what happens is forskolin increases an enzyme called adenylate cyclase, which increases levels of another enzyme called cAMP (cyclic AMP), which is found in fat. cAMP then stimulates another enzyme, hormone-sensitive lipase, to burn fat. Additionally, by a similar mechanism using cAMP, coleus increases thyroid hormone production and release, thereby increasing the body's metabolism even further. One particular study to mention by Asano Tsuguyoshi (2001), showed that ingestion of Coleus led to reduction in body weight and bodyfat and additionally a preservation of lean body mass.

*Tyrosine. As a precursor to several important neurotransmitters, tyrosine appears to have potent stimulating effects on the brain and has been shown to help individuals perform better mentally—aiding focus and alertness as well as inhibiting feelings of stress and fatigue. Several studies have also shown that supplementing with the amino acid tyrosine may be effective in altering body composition. Interestingly, though, and related to what we spoke of above, tyrosine is converted in the body to dopamine and then norepinephrine, hence its ability to enhance mood as well as potentially enhance the initiation of fat burning.

*Evodiamine has the distinctive potential to increase heat production and heat loss simultaneously, ultimately leading to the use of fat for fuel. Recent studies on mammals confirm that Evodiamine does indeed promote weight loss (Kobayashi et al). Additionally Evodiamine increases catecholamine secretion from the adrenal glands leading to stimulatory properties and cAMP activation.

Evodiamine may also potentiate weight reduction through decreasing gastric motility and transport time, along with enhancing the release of the satiety inducing CCK.

3) COGNITION COMPLEX™—Enhanced Focus and Intense, High-Speed Energy (without the Jitters)

*Xanthinol Nicotinate (XN) is a form of niacin that passes through the cell membranes. It is the most effective form of niacin available. XN stimulates memory and concentration by improving blood flow to the brain and has been shown to increase brain glucose metabolism, improve brain ATP levels, and act as a vasodilator. (This explains its ability to improve brain blood flow.) XN (like niacin) can cause a flushing of the skin and a sense of warmth. It has consequently been suggested that XN can aid weight control through heat and water loss.

*Bacopin® or Bacopa is included for its cognitive-enhancing and neuroprotective effects, specifically improvements in memory, learning, and concentration. Bacopa extracts also have a relaxant effect on chemically induced broncho-constriction.

*Vinpocetine is a powerful antioxidant, and it also enhances the delivery of glucose to the brain. Glucose is the brain's primary fuel source, and without it, the brain will shut down. Not surprisingly, athletes who supplement with vinpocetine report significant improvement in visual acuity, memory, and focus. Vinpocetine supports the brain and improves its function. Athletes also report that vinpocetine is extremely thermogenic. It causes rapid losses in bodyfat by stimulating the release of the hormone norepinephine.

iSatori Technologies developed an exclusive Rapid Bio-Diffusion Delivery™ technology, so you immediately feel the difference when you try MX-LS7."

MX-LS7 Rooted in Science: Nothing Is Stronger; Nothing Works Faster

iSatori started with a core of the finest ingredients for fat reduction. Then they built on that core with a t3/camp blend to further upregulate thermogensis and weight loss. However, no workout or formula would be complete without the cognitive blend designed to maximize workout performance, thus lending to even greater weight reduction.

After all the parts were assembled, the researchers still weren't satisfied, so they added yet another level. With the guidance of a leading pharmaceutical specialist, iSatori Technologies developed an exclusive Rapid Bio-Diffusion Delivery™ technology, which uses a sophisticated "micro-particlization" process, so MX-LS7 starts working from the very first dose to radically maximize thermogenesis and eliminate unwanted bodyfat, fast. And you immediately feel the difference when you try MX-LS7.

MX-LS7 is not to be taken lightly. It was designed for men and brave women who desire serious fat reduction. Fast. But don't take our word for it. For a limited time, Real Solutions readers can try MX-LS7 for free. Simply call 1.866.688.7679 and ask for your free sample. Or click here to find out how you can get a full bottle free. Then don't forget to let us know what you think! Email us at info@isatoritech.com.

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