ALC

How You May Benefit:

Elevate mood and well-being
Increase the activity of messengers in the brain to help relieve depression, especially in the elderly
Fight free radicals
Combat the effects of aging by fighting free radicals
Increase mental focus
Stimulate improved cognitive function by increasing neurotransmitter activity
Increase oxygen uptake
Prevent muscle damage caused by a lack of oxygen and aid the heart and lungs during endurance activities
Increase fat metabolism
Support fat loss by transporting fats into cells to be burned for energy
Improve sensory abilities
Boost neurotransmitter activity and increase blood flow to the brain

Overview

ALC (acetyl-L-carnitine) is widely used in life-extension circles for its positive impact on cognition. Its role in stimulating mental function and slowing memory loss is normally of interest to anyone of age or aging (which we hope you are). In addition, it's been found to increase energy availability to our cells and to support immune functioning.

The Full Story

Usage

Amount: There is no RDA for ALC; however, 500 mg taken 3 times per day may be effective for the above mentioned benefits.

Timing: Although some sources recommend supplementing with ALC on an empty stomach, stomach discomfort may be experienced when it is consumed without food.

ALC, the acetyl form of L-carnitine, may actually be more effective when it comes to transporting fats to muscle to be burned instead of stored. But while L-carnitine is known as a weight-loss nutrient, the popularity of ALC for its anti-aging effects far exceeds its use as a weight-loss aid. It's been shown to be especially beneficial in fighting age-related decreases in brain functioning, such as memory loss.

Safety Information

Safety:
Has not yet been determined for pregnant or breastfeeding women.

Toxicity:
None known.

Bans and Restrictions:
None reported.

References

Bowman, B.A., "Acetyl-Carnitine and Alzheimer's Disease," Nutr Rev 50.5 (1992) : 142-4.

Brooks, J.O., et al., "Acetyl-L-Carnitine Slows Decline in Younger Patients with Alzheimer's Disease: A Reanalysis of a Double-Blind, Placebo-Controlled Study Using the Trilinear Approach," Int Psychogeriatr 10.2 (1998) : 193-203.

Calvani, M., et al., "Action of Acetyl-L-Carnitine in Neurodegeneration and Alzheimer's Disease," Ann N Y Acad Sci 663 (1992) : 483-6.

Carta, A., et al., "Acetyl-L-Carnitine and Alzheimer's Disease: Pharmacological Considerations Beyond the Cholinergic Sphere," Ann N Y Acad Sci 695 (1993) : 324-6.

Garzya, G., et al., "Evaluation of the Effects of L-Acetylcarnitine on Senile Patients Suffering from Depression," Drugs Exp Clin Res 16.2 (1990) : 101-6.

Kidd, P.M., "A Review of Nutrients and Botanicals in the Integrative Management of Cognitive Dysfunction," Altern Med Rev 4.3 (1999) : 144-61.

Ruggiero, F.M., et al., "Effect of Aging and Acetyl-L-Carnitine on the Lipid Composition of Rat Plasma and Erythrocytes," Biochem Biophys Res Commun 170.2 (1990) : 621-6.

Martignoni, E., et al., "Acetyl-L-Carnitine Acutely Administered Raises Beta-Endorphin and Cortisol Plasma Levels in Humans," Clin Neuropharmacol 11.5 (1988) : 472-7.

Spagnoli, A., et al., "Long-Term Acetyl-L-Carnitine Treatment in Alzheimer's Disease," Neurology 41.11 (1991) : 1726-32.

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